https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Heritable defects in telomere and mitotic function selectively predispose to sarcomas https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:50526 Wed 28 Feb 2024 15:27:25 AEDT ]]> PAI-1 augments mucosal damage in colitis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:47717 Wed 25 Jan 2023 13:01:40 AEDT ]]> The genetic architecture of the human cerebral cortex https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:42676 Wed 22 Mar 2023 14:34:07 AEDT ]]> Comment on "PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL human leukemia" https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:48375 Wed 15 Mar 2023 13:47:42 AEDT ]]> Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:34617 Wed 09 Feb 2022 15:55:15 AEDT ]]> Persistent influence of obliquity on ice age terminations since the Middle Pleistocene transition https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:46693 Tue 29 Nov 2022 09:42:29 AEDT ]]> Enhanced interfacial electron transfer between thylakoids and RuO2 nanosheets for photosynthetic energy harvesting https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:46052 2 nanosheets to enhance the extraction of PEs from thylakoids, and the PE transfer was promoted by proton adsorption and surface polarity characteristics. The adsorbed protons maintained the potential of an electrode more positive, and the surface polarity enhanced thylakoid attachment to the electrode in addition to promoting ensemble docking between the redox species and the electrode. The RuO2 bioanode exhibited a five times larger current density and a four times larger power density than the Au bioanode. Last, the electric calculators were successfully powered by photosynthetic energy using a RuO2 bioanode.]]> Tue 29 Nov 2022 09:22:03 AEDT ]]> A Persistent Neutrophil-Associated Iimmune Signature Characterizes Post-COVID-19 Pulmonary Sequelae https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:50423 Tue 25 Jul 2023 18:33:24 AEST ]]> miRNA cargo in circulating vesicles from neurons is altered in individuals with schizophrenia and associated with severe disease https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:54330 Tue 20 Feb 2024 15:58:57 AEDT ]]> Pathophysiological regulation of lung function by the free fatty acid receptor FFA4 https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:41995 Tue 16 Aug 2022 16:37:18 AEST ]]> Coral reef structural complexity provides important coastal protection from waves under rising sea levels https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:32930 Tue 11 Oct 2022 08:56:03 AEDT ]]> Cyanobacterial α-carboxysome carbonic anhydrase is allosterically regulated by the Rubisco substrate RuBP https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:55618 Tue 11 Jun 2024 14:46:52 AEST ]]> Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:46138 Tue 04 Apr 2023 18:59:19 AEST ]]> Erasable and recreatable two-dimensional electron gas at the heterointerface of SrTiO3 and a water-dissolvable overlayer https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:45145 3Al2O6 (a-SAO) on SrTiO3 (STO) at room temperature. The 2DEG can be repeatedly erased or recreated by depositing the a-SAO or dissolving in water, respectively. Photoluminescence results show that the 2DEG arises from the a-SAO–induced oxygen vacancy. Furthermore, by gradually depleting the 2DEG, a transition of nonlinear to linear Hall effect is observed, demonstrating an unexpected interfacial band structure. The convenience and repeatability in the creation of the water-dissolvable 2DEG with rich physics could potentially contribute to the exploration of next generation electronics, such as environment-friendly or water-soluble electronics.]]> Thu 27 Oct 2022 14:25:18 AEDT ]]> Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:51168 Thu 24 Aug 2023 14:09:35 AEST ]]> microRNA-21-mediated SATB1/S100A9/NF-kappa B axis promotes chronic obstructive pulmonary disease pathogenesis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:49088 Thu 04 May 2023 13:43:05 AEST ]]> LncRNA GIRGL drives CAPRIN1-mediated phase separation to suppress glutaminase-1 translation under glutamine deprivation https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:39285 Thu 02 Jun 2022 15:26:26 AEST ]]> Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:21751 Sat 24 Mar 2018 08:03:34 AEDT ]]> Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:20277 Sat 24 Mar 2018 07:59:53 AEDT ]]> GWAS of 126,559 individuals identifies genetic variants associated with educational attainment https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:28443 Sat 24 Mar 2018 07:29:00 AEDT ]]> Dissecting the signaling pathways that mediate cancer in PTEN and LKB1 double-knockout mice https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:22856 PTEN and LKB1 - genes encoding phosphatase and tensin homolog and liver kinase B1, respectively - leads to the spontaneous development of cancer in mice. PTEN converts phosphatidylinositol (3,4,5)-trisphosphate (PIP3) to phosphatidylinositol (4,5)-bisphosphate (PIP2), whereas LKB1 activates the 5' adenosine monophosphate-activated protein kinase (AMPK). The kinase AKT and the kinase complex mTORC1 may play key roles in carcinogenesis and are components of signaling pathways that also contain PTEN and LKB1. We propose that via activation of AKT and mTORC1, the double knockout of PTEN and LKB1 contributes to distinct cell-specific aspects of tumor development and progression. Whereas mTORC1 promotes cancer initiation and progression through cell growth, survival, and proliferation, independent induction of the immune inhibitory molecule PD-L1 by activated AKT enables the tumors to evade immunosurveillance.]]> Sat 24 Mar 2018 07:16:02 AEDT ]]> Interferon-ε protects the female reproductive tract from viral and bacterial infection https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:22111 Ifn-ε–deficient mice had increased susceptibility to infection of the FRT by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum. Thus, IFN-ε is a potent antipathogen and immunoregulatory cytokine that may be important in combating STIs that represent a major global health and socioeconomic burden.]]> Sat 24 Mar 2018 07:13:18 AEDT ]]> Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:42308 Camp-/-) and exogenous cathelicidin prevented ICS-mediated expansion of streptococci within the microbiota and improved bacterial clearance. Suppression of pulmonary immunity by ICS was mediated by augmentation of the protease cathepsin D. Collectively, these data suggest a central role for cathepsin D/cathelicidin in the suppression of antibacterial host defense by ICS in COPD. Therapeutic restoration of cathelicidin to boost antibacterial immunity and beneficially modulate the lung microbiota might be an effective strategy in COPD.]]> Mon 22 Aug 2022 10:35:15 AEST ]]> Diving into the vertical dimension of elasmobranch movement ecology https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:51923 Fri 22 Sep 2023 11:00:28 AEST ]]> Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:51745 Fri 15 Sep 2023 18:22:09 AEST ]]> Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:51529 Fri 08 Sep 2023 12:10:33 AEST ]]>